The microtubule-associated protein tau may be involved in cell morphogenesis and axonal maintenance. In addition to microtubules, tau has been shown to interact with actin in vitro. In …

Jan 16, 2002 · In this study, PC12 cells were transiently transfected with constructs coding fusion proteins of human tau with green fluorescent protein (GFP). Expression of tau constructs …

Feb 23, 2024 · We developed an approach to monitor pathological changes of aggregation-prone human tau in living neurons. We identified 2-phenyloxazole (PHOX) derivatives as putative …

Dec 1, 1994 · We conclude that the residues necessary for confering microtubule nucleation activity of tau in vitro are important for process formation in vivo. It is likely that these residues …

Dec 10, 1999 · The selective distribution of phosphorylated tau in apoptotic PC12 cells indicates that tau likely plays a significant role in the cytoskeletal changes that occur during apoptosis.

PC12 cells were treated with EGF for 36 hours and the effects on tau protein and tau mRNA levels were analyzed (Figure 4A and B, lane 4). The results demonstrate an increase of tenfold in tau …

Jan 1, 1995 · We transfected undifferentiated PC12 cells with vectors expressing tau fragments and treated the expressing cells with cytochalasin B to allow process extension.

To shed light on this issue, tau phosphorylation was studied in rat PC 12 pheochro-mocytoma cells and Chinese hamster ovary (CHO) cells transfected with human tau-cDNA. Here we …

Apr 7, 2022 · The results indicate a novel toxic gain of function, in which a post-translational modification of tau changes the dynamics of the tau-microtubule interaction and thus leads to …

In this study, we investigated the effects of manganese and iron exposure, both individually and in combination, on tau hyperphosphorylation, β-amyloid (Aβ) accumulation (particularly Aβ 1-42), …